Research publications

Publications make scientific information publically available, and allow the rest of the academic audience to evaluate the quality of the research.
An innovative method for the selection of inhibitors of the viral spike-glycoprotein of the SARS-CoV.
Koshlan TV, Kulikov KG. (2020)

Modeling the impact of point mutations on the stability of proteins.
K G Kulikov , T V Koshlan (2020)

Laser Interaction with Heterogeneous Biological Tissue
Kulikov K., Koshlan T. (2018)
Analysis of Electrostatic Interaction between Dimer Complexes. Part II: Criteria and Conditions on Inhibitors of APP Protein Derivatives
We communicate the results of calculations and selection methods, and identify the properties, of inhibitors that block the formation of high-molecular-weight structures from amyloid peptides, with their block...
T. V. Koshlan, K. G. Kulikov in Technical Physics (2020)

Analysis of Electrostatic Interaction between Dimer Complexes. Part I: A Method for Selecting Inhibitors of APP Protein Derivatives
We present an unconventional method that provides qualitative evaluation of the ability of amyloid peptides to form high-molecular-weight structures and enables us to resolve the stability issue of amyloid dim...
T. V. Koshlan, K. G. Kulikov in Technical Physics (2020)

Simulation of the Effect of Point Mutations on the Stability of Protein Dimers Using the Bcl-2 Protein Family as an Example
A new method has been developed that enables synthesizing peptides with desired physicochemical properties, for example, with high affinity to one target protein and low affinity to other proteins, and determi...
T. V. Koshlan, K. G. Kulikov in Technical Physics (2020)

Analysis of Electrostatic Interactions of Amino Acid Residues by the Example of Formation of a Nap1–Nap1 Dimer
A new method, which analyzes the potential energy of electrostatic interaction of protein complexes at point replacements of amino acid residues assuming a three-dimensional structure of the complex on the exa...
T. V. Koshlan, K. G. Kulikov in Technical Physics (2020)

Mathematical Modeling of Linear Docking. II. Estimating the Effect of Point Mutations on the Affinity between Protein Molecules

A new method enabling the qualitative determination of the dissociation constant of peptides to full-length proteins and the estimation of the effect of point mutations in peptides on the stability of a formed...
T. V. Koshlan, K. G. Kulikov in Technical Physics (2018)

Mathematical Modeling of Linear Docking. I. Determination of Regions of Binding of Protein Molecules
We report on the results of mathematical simulation of the interaction of various sequences of proteins Mdm2, P53, and Nap1 in accordance with the developed algorithms that were used for identifying the region...
K. G. Kulikov, T. V. Koshlan in Technical Physics (2018)

Mathematical modeling of the temperature effect on the character of linking between monomeric proteins in aqueous solutions
This work is devoted to the mathematical modeling of the temperature effect on the stability of H2A–H2B and Н3–H4 histone dimers by studying their behavior in different temperature regimes of 20–50°C. The stud...
T. V. Koshlan, K. G. Kulikov in Technical Physics (2017)

Mathematical modeling the formation of a histone octamer
A physical model of the interaction of protein molecules and their ability to form complex biological systems for the in vitro case in a solution of monovalent salt has been developed. Their reactive abilities...
T. V. Koshlan, K. G. Kulikov in Technical Physics (2017)

Mathematical simulation of complex formation of protein molecules allowing for their domain structure
A physical model of the interactions between protein molecules has been presented and an analysis of their propensity to form complex biological complexes has been performed. The reactivities of proteins have ...
T. V. Koshlan, K. G. Kulikov in Technical Physics (2017)

Mathematical simulation of interactions of protein molecules and prediction of their reactivity
A physical model of interactions of protein molecules has been developed. The regularities of their reactivity have been studied using electrostatics methods for two histone dimers H2A–H2B and H3–H4 assembled ...
K. G. Kulikov, T. V. Koshlan in Technical Physics (2016)

Measurement of sizes of colloid particles using dynamic light scattering
Size distribution functions of colloid particles are obtained with the aid of dynamic light scattering for both polarized and depolarized components. Electron microscopy of the colloid particles is used to con...
K. G. Kulikov, T. V. Koshlan in Technical Physics (2015)

Simulation of the type of coralin alkaloid-DNA binding
Interaction between a synthesized coralin protoberberine alkaloid and the DNA double helix of the calf's thymus in a salt solution is studied by optical absorption spectroscopy and spectropolarimetry. The depe...
K. G. Kulikov, T. V. Koshlan in Technical Physics (2015)

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